Cisplatin is a platinumbased agent whose nephrotoxicity is thought related to the chloride in the cis position. Oncology 22 453 if you know of a relevant reference for cisplatin, please let us know. Inside the cell, the chloride atoms of cisplatin may be displaced and the compound may be inactivated directly by. Carboplatin is one of the platinumbased anticancer drugs and its parent compound is cisplatin. Jul 18, 2017 in these reports, cisplatin cisplatin injection was generally given in combination with other leukemogenic agents.
Eurtac phase iii study design erlotinib 150 mgday cisplatin docetaxel, cisplatin gemcitabine. The first step in the process after the cisplatin molecule penetrates the cell membrane intact is for a molecule of water to replace one of the chloride ions. Cisplatin may also be used for purposes not listed in this medication guide. While a combinationchemotherapy with cisplatin is a cornerstone for the treatment of multiple cancers, the challenge is that cancer cells could become cisplatin resistant. Webmd provides common contraindications for cisplatin intravenous. Cisplatin kills cells including cancer cells and normal cells by causing abnormal linkages in dna, the genetic material of cells. History of the great invention in science discovery of cisplatin author. Definition from the nci drug dictionary detailed scientific definition and other names for this drug. It was the first member of its class, which now also includes carboplatin and. If blood cell counts get very low, this can lead to bleeding problems, infections, or anemia.
Hci andor sodium hydroxide added to adjust ph to 3. Clinical use, toxicity and mechanism of resistance of cisplatin while strong expression in inner and outer hairy cells of organ of corti was observed in the cisplatin group, cells showing a rather strong tunelpositive reaction were detected figure 2. Cancer commons is a patientcentric, nonprofit network of patients, physicians, and scientists that helps identify the best options for treating an individuals cancer. Pharmacology, clinical uses and adverse effects pharmacology research, safety testing and regulation. Its cytotoxic mode of action is mediated by its interaction with.
Oct 05, 2014 cisplatin is stable under normal temperatures and pressures, but may transform slowly over time to the transisomer iarc 1981, akron 2009. Jul 18, 2017 cisplatin injection cisplatin injection cisplatin cisplatin injection injection is a sterile aqueous solution, available in 50, 100 and 200 ml multiple dose vials, each ml containing 1 mg of cisplatin cisplatin injection and 9 mg sodium chloride in water for injection. Measles, mumps and rubella vaccine, live is predicted to increase the risk of generalised infection possibly lifethreatening when given with cisplatin. Cisplatin is prescribed for the treatment of various types of cancer, including ovarian cancer, testicular cancer, and bladder cancer. Cisplatin article about cisplatin by the free dictionary. Download fulltext pdf download fulltext pdf download fulltext pdf.
Cisplatin or cisdiamminedichloroplatinum cddp is the first member of a class of platinumcontaining anticancer drugs that act by binding to and causing crosslinking of deoxyribonucleic acid, which ultimately triggers apoptosis. Cisplatin side effects, dosage, interactions drugs. Clinical use, toxicity and mechanism of resistance of cisplatin while strong expression in inner and outer hairy cells of organ of corti was observed in the cisplatin group, cells showing a rather strong tunelpositive reaction were. Docetaxel plus cisplatin has not been compared with cisplatin plus fluorouracil in a randomized phase iii trial. Cisplatin is also being studied in the treatment of other types of cancer. Cisplatin dosing, indications, interactions, adverse. Nomura et al 2004 cisplatin inhibits the expression of xlinked inhibitor of apoptosis protein in human lncap cells.
Disposition of total and free cisplatin on two consecutive. The active ingredient, cisplatin, is a yellow to orange crystalline powder with the molecular formula ptcl. Like any drug that damages cells it has side effects. Im six years out and have some dings from the treatment but would do it again. Cisplatin is used together with other medications to treat bladder cancer, testicular cancer, or ovarian cancer cisplatin may also be used for purposes not listed in this medication guide. This chemotherapy medication is designed to kill cancer cells and normal cells by causing abnormal linkages in dna. Cisplatin dosing, indications, interactions, adverse effects. Special attention is given to the synthesis of the compound and related derivatives, and to the nature of the hydrolysis products in blood and in the cell. Cisplatin is one of the most successful chemotherapeutics and has been widely used in clinics for the treatment of various cancers including bladder, head and neck, lung, ovarian, and testicular cancers. Gastrointestinal marked nausea and vomiting occur in almost all patients treated with cisplatin cisplatin injection, and are occasionally so severe that the drug must be discontinued. This interferes with normal transcription andor dna replication mechanisms and triggers cytotoxic processes that lead to cell death. Each vial of platinol contains 50 mg cisplatin, 450 mg sodium chloride, usp, and 500 mg mannitol, usp.
Cisplatin definition of cisplatin by medical dictionary. Cisplatin, cisplatinum or cisdiamminedichloridoplatinumii cddp is a platinumbased chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas e. Cellular apoptosisnecrosis develops due to endoplasmic reticuluminduced stress, mitochondrial injury pathways, and a death receptor. There are many options to help minimize or prevent the side effects of cisplatin. The cytotoxicity of cisplatin correlates with cellular arrest in the g2 phase of the cell cycle.
Side effects of cisplatin cisplatin injection, warnings, uses. These include testicular cancer, ovarian cancer, cervical cancer, breast cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. Broadening the chemotherapeutic arsenal depends on understanding existing agents with a view toward developing new modes of attack. May use concomitant amifostine to decrease nephrotoxicity. Cisplatin terry clayton biological inorganic chemistry april 1, 2007 slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. The current accepted paradigm about cisplatin mechanism of action is that. Cisplatin is part of a group of medications called platinum analogues. Nausea was the worst for me, they gave me compazine and ataivan not sure of spelling alternating every 4 hours still had nausea but perhaps. Cisplatin is a chemotherapy medication used to treat a number of cancers. Mechanism of action cisplatin is believed to kill cancer cells by binding to dna and interfering with its repair mechanism, eventually leading to cell death. After undergoing hydrolysis, it reacts with dna to produce both intra and interstrand crosslinks. Jul 20, 2018 how does cisplatin work to treat cancer. It has been used for treatment of numerous human cancers including bladder, head and neck, lung.
Find out what health conditions may be a health risk when taken with cisplatin intravenous. There is an option for colored glasses, but youtube does the. Cisplatin is used together with other medications to treat bladder cancer, testicular cancer, or ovarian cancer. Erlotinib vs chemotherapy ct in advanced nonsmallcell lung cancer nsclc patients p with epidermal growth factor receptor egfr activating mutations. This medicine may lower the ability of the bone marrow to make blood cells that the body needs.
Cisplatin has a broadspectrum antineoplastic activity against various types of human tumors. Cisplatin supplier cas 15663271 cddp tocris bioscience. If you continue browsing the site, you agree to the use of cookies on this website. Cisplatin is a medicine used alone or with other therapies to treat cancer of the testicles, ovaries, or bladder the drug is also sometimes used offlabel to treat head and neck. Plasma samples obtained up to 4 h after cisplatin infusion contained measurable ultrafilterable free cisplatin. The mean disposition of free cisplatin conformed to a twocompartment model with a mean terminal halflife sd of 46.
Numerous mechanisms of cisplatin resistance were described including. Story of cisplatin free download as powerpoint presentation. The following side effects are common occurring in greater than 30% for patients taking cisplatin. Cisplatin is used to treat various types of cancer.
Cisplatin is administered intravenously as shortterm infusion in normal saline for treatment of solid and haematological malignancies. Medlineplus information on cisplatin a lay language summary of important information about this drug that may include the following. It is used as an antineoplastic agent in the treatment of metastatic tumors of the testis. Synthesis, antitumour activity and mechanism of action. Cisplatin injection cisplatin injection cisplatin cisplatin injection injection is a sterile aqueous solution, available in 50, 100 and 200 ml multiple dose vials, each ml containing 1 mg of cisplatin cisplatin injection and 9 mg sodium chloride in water for injection.
Mechanism of action of cisplatin has been broadly investigated in the past decades. A special attention is given to its molecular mechanisms of action, historical background, undesirable side effects. Major side effect, action pharmacology mnemonics the best internal medicine question bank with questions, videos flashcards, and mnemonics. It is used to treat various types of cancers, including sarcomas, some carcinomas e. In the 35 years since the discovery of the antitumor activity of cisplatin, laboratory studies have provided considerable information as to how the drug exerts its antitumor effects and how some tumors are, or become, resistant to. While a combinationchemotherapy with cisplatin is a cornerstone. Inside the cell, the chloride atoms of cisplatin may be displaced and the compound may be inactivated directly by reaction with nucleophiles such as thiols. It also belongs to a larger group of chemotherapy drugs known as alkylating agents. Cisplatin, cisplatinum, or cisdiamminedichloroplatinum ii, is a wellknown chemotherapeutic drug.
Cisplatin gains entry into tubular cells via uptake by the oct2 system on the basolateral membrane of proximal tubular cells. Anderson cancer center, 1515 holcombe boulevard, houston, tx 770304009, usa cisplatin is one of the most potent antitumor agents. The drug comes in injectable form, and is typically administered by a healthcare provider. Cisplatin interactions bnf content published by nice. In the 35 years since the discovery of the antitumor activity of cisplatin, laboratory studies have provided considerable information as to how the drug exerts its antitumor effects and how some tumors are, or become, resistant to this drug. Sep 12, 2019 cisplatin is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body. Interim results of the european erlotinib vs chemotherapy eurtac phase iii randomized trial rosell r et al.
It has been used for treatment of numerous human cancers including bladder, head. The main mechanism of the cytotoxic action involves the binding of cisplatin to genomic dna in the cell nucleus to form interstrand and intrastrand crosslinks. These crosslinks appear to impair replication and transcription of dna. Cisplatin is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body. Molecular mechanisms of cisplatin resistance oncogene. Had modified rnd, cisplatin, carboplatin, erbitux and taxol, and 33 rounds of radiation not an unusual treatment. Cisplatin is one of the most potent antitumor agents known, displaying clinical activity against a wide variety of solid tumors. This medicine is used to treat many types of cancer like bladder, ovarian, and testicular cancers. Cisplatin is stable under normal temperatures and pressures, but may transform slowly over time to the transisomer iarc 1981, akron 2009. Although cisplatin, cisdiamminedichloroplatinumii, has been successfully used in the chemotherapy of cancer for more than 25 years, its biochemical mechanism of action is still unclear. There is no relationship between the presence or severity of cisplatin side effects and effectiveness of cisplatin. May 14, 2018 broadening the chemotherapeutic arsenal depends on understanding existing agents with a view toward developing new modes of attack. Cellular mechanisms of activity, drug resistance and induced side effects anamaria florea 1 and dietrich busselberg 2, 1 department of neuropathology.